Sunday, October 13, 2019

Vaccine reactions by shot


Hep A+Hep B (Twinrix)- headache, fatigue, diarrhea, nausea, fever, vomiting, upper respiratory tract infection, anorexia, agitation, insomnia, dizziness, migraine, paresthesia, somnolence, syncope, vertigo, erythema, rash, sweating, back pain, myalgia, lymphadenopathy, dysgeusia, photophobia, hypotension, herpes zoster, meningitis, Bell's palsy, convulsions, Guillain- Barre syndrome, multiple sclerosis, neuritis, earaches, tinnitus, palpitations, hepatitis, jaundice, eczema, lichen planus, arthritis, chills

Hep B (Engerix-B)- herpes zoster, meningitis, thrombocytopenia, anaphylaxis, hypersensitivity syndrome, encephalitis, encephalopathy, migraine, multiple sclerosis, neuritis, neuropathy, Guillain- Barre syndrome, Bell's palsy, optic neuritis, seizures, syncope, earaches, tinnitus,
vertigo, palpitations, asthma, eczema, alopecia, lichen planus, purpura, arthritis, muscular weakness, abnormal liver function tests, anorexia, insomnia

Hep B (Recombivax)- fatigue, weakness, high fever, nausea, diarrhea, pharyngitis, upper respiratory infection, sweating, chills, diminished appetite, rhinitis, influenza, cough, vertigo/dizziness, paresthesia, pruritus, rash, angioedema, myalgia, back pain, lymphadenopathy, insomnia, earaches, dysuria, hypotension, elevation of liver enzymes, constipation, Guillain-Barre syndrome, multiple sclerosis, seizures, febrile seizures, herpes zoster, encephalitis, eczema, arthritis, extreme pain, lupus-like syndrome

HPV (Cervarix)- extreme pain, headache, nasopharyngitis, influenza, dizziness, upper respiratory infection, dysmenorrhea, chlamydia infection, pharyngitis, injection site bruising, vaginal infection, back pain, UTI, arthritis, celiac disease, dermatomyositis, diabetes, hyperthyroidism, hypothyroidism, inflammatory bowel disease, psoriasis, death, allergies, vitiligo, seizures

HPV (Gardasil)- headache, fever, nausea, arthritis, death, autoimmune thyroiditis, celiac disease, inflammatory bowel disease, multiple sclerosis, nephritis, pigmentation disorder, diabetes, chills, fatigue, malaise, autoimmune disease, seizures, cellulitis, deep venous thrombosis

Influenza (Fluzone: High dose)- myalgia, malaise, headache, fever, thrombocytopenia, lymphadenopathy, anaphylaxis, ocular hyperemia, Guillain- Barre syndrome, convulsions, Bell's palsy, brachial neuritis, syncope (shortly after vaccination), dizziness, rhinitis, cough, wheezing, chest pain, vomiting, nausea, diarrhea, chills

Influenza (Fluvirin)- pain, headache, fatigue, fever, sweating, arthralgia, myalgia, malaise, sore throat, chills, nausea, cough, wheezing, stroke, hypersensitivity reactions, vasculitis, loss of appetite, confusion, febrile seizures, Guillain- Barre syndrome, urticaria, rash, cellulitis, encephalopathy

Influenza (Flulaval)- Guillain- Barre syndrome, syncope (fainting), headache, fatigue, malaise, sore throat, cough, chills, facial swelling, diarrhea, lymphadenopathy, eye pain, photophobia, dysphagia, chest pain, allergies, anaphylaxis, angioedema, rhinitis, laryngitis, cellulitis, arthritis, dizziness, tremors, seizures, limb paralysis, insomnia, bronchospasm, throat tightness

Influenza (FluMist)- wheezing, runny nose, decreased appetite, lethargy, chills, high fever, pericarditis, genetic disorders, nausea, vomiting, diarrhea, hypersensitivity, Guillain- Barre syndrome, Bell's Palsy, meningitis, vaccine- associated encephalitis, rash

Meningococcal ( MCV4-Menactra)- diarrhea, drowsiness, anorexia, arthralgia, fever, rash, vomiting, seizure, headache, chills, hypersensitivity reactions such as anaphylaxis/ anaphylactic reaction, wheezing, difficulty breathing, upper airway swelling, urticaria, erythema, pruritus,
hypotension, Guillain- Barre syndrome, paraesthesia, vasovagal syncope, dizziness, convulsion, facial palsy, acute disseminated encephalomyelitis, transverse myelitis, myalgia

Meningococcal (MCV4- Menveo)- irritability, sleepiness, persistent crying, change in eating habits, vomiting, diarrhea, rash, fever, appendicitis, pneumonia, staphylococcal infection, inguinal hernia, abdominal pain, labor pneumonia, viral hepatitis, hearing impaired, vertigo, hypersensitivity, vaccination site cellulitis, tonic convulsions

Meningococcal (Menomune)- injection site pain, irritability, diarrhea, headache, fatigue, anorexia, vomiting, seizures, rash, chills, fever, vasovagal syncope, Guillain- Barre syndrome, myalgia, arthralgia, urticaria, pruritus, dyspnea, dizziness, paresthesia

MMRV (Proquad)- fever, irritability, measles-like rash, varicella-like rash, rash, upper respiratory infection, viral exanthema, diarrhea, rubella-like rases, rhinorrhea, atypical measles, candidiasis, cellulitis, herpes zoster, infection, influenza, measles, respiratory infection, varicella (vaccine strain), anaphylaxis, pneumonia, afebrile seizures, aseptic meningitis, Bell's Palsy, dizziness, ear pain, nerve deafness, bronchial spasms, eczema, death

Pneumococcal (PCV13- Prevnar13)- bronchiolitis, gastroenteritis, pneumonia, sudden infant death syndrome (SIDS), fever, decreased appetite, irritability, increased or decreased sleep, diarrhea, vomiting, rash, inconsolable crying, hypersensitivity, seizures, urticaria, anaphylactic/anaphylactoid reaction including shock, apnea

Pneumococcal (PPSV-23-Pneumovax)- cellulitis, malaise, fever above 102, decreased limb mobility, nausea, vomiting, lymphadenitis, lymphadenopathy, leukocytosis, anaphylactoid reactions, serum sickness, angioneurotic edema, arthritis, paresthesia, radiculoneuropathy, Guillain- Barre syndrome, febrile seizures, rash, urticaria, back pain, upper respiratory infection, chills, myalgia, headache, angina pectoris, heart failure, chest pain, ulcerative colitis, depression, cerebrovascular accident, lumbar radiculopathy, pancreatitis/ myocardial infarction resulting in death

Polio (IPV-Ipol)- Ipol vaccine is contraindicated in persons with a history of hypersensitivity toany componen t of the vaccine, including -phenoxyethanol, formaldehyde, neomycin, streptomycin, and polymyxin B. Deaths have been reported in temporal association with the IPV vaccine. High fever, irritability, anorexia, vomiting, persistent crying, GBS, lymphadenopathy, agitation, injection site mass, type 1 hypersensitivity including allergic reaction, anaphylactic reaction, anaphylactic shock, arthralgia, myalgia, convulsions, febrile convulsions, headache, paraesthesia, somnolence, rash, urticaria

Rotavirus (RotaTeq)- bronchiolitis, gastroenteritis, pneumonia, fever, UTI, sudden infant death syndrome (SIDS), hematochezia, seizures, kawasaki disease, vomiting, diarrhea, irritability, anaphylactic reaction, intussusception (including death), urticaria, angioedema, “RotaTeq has not been evaluated for its carcinogenic or mutagenic potential or its potential to impair fertility.”

Rotavirus (Rotarix)- fussiness, cough/ runny nose, fever, loss of appetite, vomiting, diarrhea, death mostly caused by pneumonia, kawasaki disease, intussusception (including death), recurrent intussusception (including death), hematochezia, gastroenteritis with vaccine trial shedding in infants with severe combined immunodeficiency disease (SCID)

Tdap (Boostrix)- hypersensitivity, anaphylaxis, coma, decreased level of consciousness, prolonged seizures, Guillain- Barre syndrome, brachial neuritis, syncope, progressive or unstable neurologic disorders, Arthus- type hypersensitivity, headache, fatigue, gastrointestinal symptoms, fever, lymphadenitis, allergic reaction such as anaphylactic and anaphylactoid reactions, myocarditis, injection site mass, back pain, convulsions (with and without fever), encephalitis, facial palsy, loss of consciousness

Tdap (Adacel)- headache, body ache, tiredness, chills, sore and swollen joints, nausea, lymph node swelling, diarrhea, vomiting, rash, anaphylactic reaction, hypersensitivity reaction, Guillain- Barre syndrome, brachial neuritis, facial palsy, convolutions, syncope, myositis, myocarditis, pruritus, extensive limb swelling Varicella (Varivax)- fever, varicella-like rash, anaphylaxis (including anaphylactic shock), pneumonia, facial edema, necrotizing, retinitis, aplastic anemia, thrombocytopenia, varicella (vaccine strain), encephalitis, Guillain- Barre syndrome, Bell's palsy, non- febrile seizures, aseptic meningitis, dizziness, paresthesia

Zoster (shingles-Zostavax)- injection pain/ swelling, erythema, pruritus, congestive heart failure, deaths caused by cardiovascular disease, nausea, herpes zoster (vaccine strain), rash, arthralgia, myalgia, respiratory infection, fever, rhinitis, skin disorder, diarrhea


Covid 19 from Pfizer

Blood thrombosis.
Acute kidney injury,
Acute flaccid myelitis,
Positive antisperm antibodies,
Brainstem embolism,
Brainstem thrombosis,
Cardiac arrest (hundreds of cases),
Heart failure,
Cardiac ventricular thrombosis,
Cardiogenic shock,
Central nervous system vasculitis,
Neonatal death,
Deep vein thrombosis,
Brainstem encephalitis,
Hemorrhagic encephalitis,
Frontal lobe epilepsy,
Foaming at the mouth,
Epileptic psychosis,
Facial paralysis,
Fetal distress syndrome,
Gastrointestinal amyloidosis,
Generalized tonic-clonic seizure,
Hashimoto's encephalopathy,
Hepatic vascular thrombosis,
Herpes zoster reactivation,
Hepatitis  Immune-mediated, 
Interstitial lung disease, 
Jugular vein embolism, 
Juvenile myoclonic epilepsy, 
Liver damage, 
Low birth weight, 
Multisystem inflammatory syndrome in children, 
Myocarditis, 
Neonatal seizure, 
Pancreatitis, 
Pneumonia, 
Stillbirth, 
Tachycardia, 
Temporal lobe epilepsy, 
Testicular autoimmunity, 
Thrombotic stroke, 
Type 1 diabetes mellitus, 
Neonatal venous thrombosis, 
Vertebral artery thrombosis, 
Pericarditis, 
Sudden death.”
 

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Asymptomatic Transmission & Shedding


The likely epidemiological sources of the transmitted mumps virus were children who were recently vaccinated with the mumps vaccine containing Leningrad-Zagreb or Leningrad-3 MuV. The etiology of the described cases of the horizontal transmission of both mumps vaccine viruses was confirmed by PCR with the sequential restriction analysis.

https://www.ncbi.nlm.nih.gov/pubmed/24772647
The likely epidemiological source of the transmitted L-3 mumps virus was children who were recently vaccinated at the schools attended by the six symptomatic mumps patients described here

https://www.ncbi.nlm.nih.gov/pubmed/16266774
Mumps outbreak in Netherlands linked to those vaccinated twice with MMR:

http://wwwnc.cdc.gov/eid/article/20/4/13-1681_article
We found 18 reports of measles outbreaks in very highly immunized school populations where 71% to 99.8% of students were immunized against measles. Despite these high rates of immunization, 30% to 100% (mean, 77%) of all measles cases in these outbreaks occurred in previously immunized students. In our hypothetical school model, after more than 95% of schoolchildren are immunized against measles, the majority of measles cases occur in appropriately immunized children.

https://www.ncbi.nlm.nih.gov/pubmed/8053748
Measles virus RNA was detected as early as 1 day or as late as 14 days after vaccination. Measles virus RNA was also detected in the urine samples from all four of the young adults between 1 and 13 days after vaccination. This assay will enable continued studies of the shedding and transmission of measles virus and, it is hoped, will provide a rapid means to identify measles infection, especially in mild or asymptomatic cases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC228449/
Measles virus was isolated in a throat swab taken 4 days after fever onset. This virus was then further genetically characterised as a vaccine-type virus

http://www.sciencedirect.com/science/article/pii/S0264410X01004959
An infant boy with a congenital immunodeficiency had fatal disseminated measles after administration of a live attenuated measles vaccine


https://www.jpeds.com/article/S0022-3476(94)70318-3/fulltext

BROTHER-TO-SISTER TRANSMISSION OF MEASLES AFTER MEASLES, MUMPS, AND RUBELLA IMMUNISATION


https://www.sciencedirect.com/science/article/pii/S0140673689912749


We describe excretion of measles vaccine strain Schwarz in a child who developed a febrile rash illness eight days after primary immunisation against measles, mumps and rubella

https://www.eurosurveillance.org/content/10.2807/ese.15.35.19652-en
We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination


https://academic.oup.com/cid/article/29/4/855/451603/
SEVERAL acute systemic viral illnesses have been associated with the presence of multinucleated giant cells or inclusion-bearing cells (or both) detected in nasal discharges1 and specimens of urine in human patients. Such cells have also been observed in the urinary sediments of children vaccinated with poliovirus and measles

https://www.nejm.org/doi/full/10.1056/NEJM196609082751002
Small Pox vaccine sheds to toddler from parent (military personnel)

 http://mobile.nytimes.com/2007/05/18/health/18smallpox.html
A 12-month-old healthy boy had approximately 30 vesicular skin lesions 24 days after receiving varicella vaccine. Sixteen days later his pregnant mother had 100 lesions. Varicella-vaccine virus was identified by polymerase chain reaction in the vesicular lesions of the mother. This case documents transmission of varicella-vaccine virus from a healthy 12-month-old infant to his pregnant mother.

http://www.ncbi.nlm.nih.gov/pubmed/9255208
Zostavax contains live attenuated VZV, and the package insert warns newly vaccinated individuals to avoid contact for an unspecified time with newborn infants, immunosuppressed individuals, and pregnant women who have not had chicken pox or have not been immunized for chicken pox. Because VZV DNA is present in saliva of zoster patients for at least 2 weeks [5] and VZV in saliva can also be infectious [6], we examined the inoculation site and saliva of Zostavax-vaccinated subjects for the presence of VZV DNA for 4 weeks after immunization”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096786/

“Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied.”

http://www.ncbi.nlm.nih.gov/pubmed/21477676
“The RotaTeq vaccine contains five live, attenuated strains derived through laboratory reassortment of human rotavirus strains with a bovine rotavirus strain. Three RotaTeq strains each contain a single human rotavirus gene segment and ten bovine rotavirus segments, and two strains contain two human strain segments and nine bovine strain segments. In the study, RotaTeq was detected in 16 stool samples. Ten of these contained between one and four individual vaccine component strains. Six samples were found to contain a vaccine-derived G1P[8] (vdG1P[8]) strain. vdG1P[8] is believed to be the product of a genetic reassortment event in which the G1 gene segment of strain WI79-9 is inserted into strain WI79-4, as evidenced by the association of G1-VP7 and P[8]-VP4 human rotavirus genes with the M2-VP3 and I2-VP6 of the bovine rotavirus. Donato et al. observed that approximately a fifth of the infants having diarrhea within 2 weeks of rotavirus vaccination were shedding vaccine strain components exclusive of any detectable enteric pathogen.”

http://www.ncbi.nlm.nih.gov/pubmed/23249230

Post-marketing experience suggests that transmission of vaccine virus may occur rarely between healthy vaccinees who develop a varicella-like rash and healthy susceptible contacts. Transmission of vaccine virus from a mother who did not develop a varicella-like rash to her newborn infant has been reported.
Due to the concern for transmission of vaccine virus, vaccine recipients should attempt to avoid whenever possible close association with susceptible high-risk individuals for up to six weeks following vaccination with VARIVAX

https://www.merck.com/product/usa/pi_circulars/v/varivax/varivax_pi.pdf

Rotavirus shedding in stool occursafter vaccination with peak excretion occurring around Day7after Dose

https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Rotarix/pdf/ROTARIX-PI-PIL.PDF

Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus (VZV) DNA in swabs of skin inoculation sites obtained immediately after immunization. vaccine virus DNA is shed in saliva up to 4 weeks

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096786/
conclude that acellular vaccines may well have contributed to -- even exacerbated -- the recent pertussis outbreak by allowing infected individuals without symptoms to unknowingly spread pertussis multiple times in their lifetimes

https://www.sciencedaily.com/releases/2015/06/150624071018.htm
Investigation of a measles outbreak in a fully vaccinated school population including serum studies before and after revaccination

http://www.ncbi.nlm.nih.gov/pubmed/8483623
According to statistics, the majority of outbreaks occur in populations where the majority of individuals were previously vaccinated.

http://aje.oxfordjournals.org/content/139/1/77.short
Correction: This article and an accompanying video previously included a photograph of a child with a rash linked to a vaccination. The image has been removed.


https://www.cnn.com/2019/01/26/health/washington-state-measles-state-of-emergency/index.html

Clark County Public Health said 3 people suspected of having measles earlier this week had rashes, but those rashes were simply reactions to the MMR vaccine and not the measles virus. 

https://www.koin.com/news/health/officials-3-thought-to-have-measles-only-had-vaccine-rash/1768866526

Examples:
CORRECTION:  An earlier version of this story showed a file photograph of a child who had an adverse reaction to the MMR vaccine.  Due to an editing error, the child was misidentified in the caption as having measles. CBSDFW apologizes for the error.

https://dfw.cbslocal.com/2019/04/08/us-measles-tally-hits-465-with-most-illnesses-in-kids/
Seattle Children's Hospital says the patient was one of its nurses who was working with a child who had contracted measles. They say she was fully vaccinated and was wearing protective equipment but still contracted the disease anyway.

https://q13fox.com/2019/07/15/another-measles-case-reported-in-king-county/
Officials said specialized laboratory testing was done after it was learned that the child had been vaccinated days before being diagnosed with measles. The tests determined that the child was experiencing symptoms of a vaccine reaction, rather than measles.

https://www.wmur.com/article/health-officials-measles-keene-vaccine/27571684
The child is vaccinated, did not have any serious complications, and is fully recovered from the disease

https://www.pressherald.com/2019/05/21/maine-cdc-reports-first-measles-case-during-nationwide-outbreak/

The child is vaccinated, did not have any serious complications, and is fully recovered from the disease

https://www.pressherald.com/2019/05/21/maine-cdc-reports-first-measles-case-during-nationwide-outbreak/

University of Florida spokesperson Steve Orlando confirmed there are 24 cases of the mumps on campus. All 24 students were vaccinated.

https://www.wtsp.com/mobile/article/news/health/24-cases-of-the-mumps-confirmed-at-the-university-of-florida/67-2631e0fd-87ab-4e7b-b786-70cb8394a15f
McCabe said she was vaccinated twice and tested positive for presumed immunity against measles three times in the last 20 years

https://local21news.com/news/local/fully-vaccinated-doctor-says-she-is-2nd-confirmed-measles-case-in-york-county

The person was fully immunized but came into contact with an 11-month-old San Diego resident who contracted the disease after a recent trip to the Philippines.

https://www.10news.com/news/local-news/san-diego-county-records-second-case-of-measles-this-year

The Student Health Center says all of the students had received required doses of the vaccine to prevent mumps.

http://www.ksdk.com/news/health/four-confirmed-mumps-cases-at-mizzou/346486122

Even those who have been fully vaccinated can still catch the disease, and so far all of the children who have caught the virus were vaccinated, Smith said

https://www.arkansasonline.com/news/2016/sep/13/mumps-ousters-criticized-20160913-1/#/

All students effected up to date.

http://abcnews.go.com/Health/video/mumps-cases-reported-nj-college-23380716

The public health department in Cambridge, Mass., where Harvard is located, determined a month ago that all infected students to that point had received a mumps vaccine prior to contracting the infection

https://www.cbsnews.com/news/nearly-a-dozen-harvard-students-isolated-amid-mumps-outbreak/

Some 97% of those in the Ohio outbreak have been vaccinated

https://www.cnn.com/2014/03/24/health/ohio-mumps
The Navy's Bureau of Medicine and Surgery (BUMED) later explained to BI that "based on clinical presentation and laboratory testing, these cases are currently classified as probable cases of mumps," one of a number of illnesses that all US military personnel are vaccinated against


https://www.businessinsider.com/uss-fort-mchenry-sailors-are-still-falling-ill-in-viral-mumps-outbreak-2019-3
 A whooping cough outbreak is causing concern in Summit County as 19 children have been diagnosed, and it's the first time in years Park City schools have seen a case of pertussis.
Officials said all of the children who have been diagnosed were vaccinated against the illness.

https://fox13now.com/2015/03/27/19-kids-in-summit-co-diagnosed-with-whooping-cough-despite-being-up-to-date-on-vaccinations/


info from https://delawaremfa.org/

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Autism


Hypothesis: conjugate vaccines may predispose children to autism spectrum disorders.

the potential effects of conjugate vaccines on neural development merit close examination. Conjugate vaccines fundamentally change the manner in which the immune systems of infants and young children function by deviating their immune responses to the targeted carbohydrate antigens from a state of hypo-responsiveness to a robust B2 B cell mediated response. This period of hypo-responsiveness to carbohydrate antigens coincides with the intense myelination process in infants and young children, and conjugate vaccines may have disrupted evolutionary forces that favored early brain development over the need to protect infants and young children from capsular bacteria.

Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism.

Considering an autoimmunity and autism connection, brain autoantibodies to myelin basic protein (anti-MBP) and neuron-axon filament protein (anti-NAFP) have been found in autistic children. In this current study, we examined associations between virus serology and autoantibody by simultaneous analysis of measles virus antibody (measles-IgG), human herpesvirus-6 antibody (HHV-6-IgG), anti-MBP, and anti-NAFP. We found that measles-IgG and HHV-6-IgG titers were moderately higher in autistic children but they did not significantly differ from normal controls. Moreover, we found that a vast majority of virus serology-positive autistic sera was also positive for brain autoantibody: (i) 90% of measles-IgG-positive autistic sera was also positive for anti-MBP; (ii) 73% of measles-IgG-positive autistic sera was also positive for anti-NAFP; (iii) 84% of HHV-6-IgG-positive autistic sera was also positive for anti-MBP; and (iv) 72% of HHV-6-IgG-positive autistic sera was also positive for anti-NAFP. This study is the first to report an association between virus serology and brain autoantibody in autism; it supports the hypothesis that a virus-induced autoimmune response may play a causal role in autism.

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and
neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of ฮฑ-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders.”

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure “Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarminglyon the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.”

Acetaminophen use after measles-mumps-rubella vaccination was SIGNIFICANTLY associated with autistic disorder when considering children 5 years of age or less, after limiting cases to children with regression in development and when considering only children who had post-vaccination sequelae adjusting for age, gender, mother’s ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was
not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.
A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted”

“Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.  “In summary, the present study documents that exposure of infant rats to THIM perturbs the balance between excitatory and inhibitory amino acids in the brain, shifting it toward excessive neuroexcitation. Despite of intrinsic limitations, present findings have important clinical implications, as they provide a plausible mechanism, whereby THIM exerts neurotoxic effects in the brain. It is likely that this mercurial—still present in pediatric vaccines in many countries—causes a similar disturbance of excitatory and inhibitory neurotransmitters in the brains of human infants, leading to neurotoxicity, encephalopaties, and in consequence to
neurodevelopmental disorders, including autism..*On the whole, the current study provides further empirical evidence that exposure to THIM leads to neurotoxic changes in the developing brain, arguing for urgent and permanent removal of this preservative from all vaccines for children (and adults) since effective, less toxic and less costly alternatives are available. The stubborn insistence of some vaccine manufacturers and health agencies on continuation of use of this proven neurotoxin in vaccines is testimony of their disregard for both the health of young generations and for the environment.*

Thimerosal, an organomercurial added as a preservative to some vaccines, is a suspected iatrogenic factor, possibly contributing to paediatric neurodevelopmental disorders including autism. We examined the effects of early postnatal administration of thimerosal (four i.m. injections, 12 or 240 ฮผg THIM-Hg/kg, on postnatal days 7, 9, 11 and 15) on brain pathology in Wistar rats. Numerous neuropathological changes were observed in young adult rats which were treated postnatally with thimerosal. They included: ischaemic degeneration of neurons and “dark” neurons in the prefrontal and temporal cortex, the hippocampus and the cerebellum, pathological changes of the blood vessels in the temporal cortex, diminished synaptophysin reaction in the hippocampus, atrophy of astroglia in the hippocampus and cerebellum, and positive caspase-3 reaction in Bergmann astroglia. These findings document neurotoxic effects of thimerosal, at doses equivalent to those used in infant vaccines or higher, in developing rat brain, suggesting likely involvement of this mercurial in neurodevelopmental disorders.
“Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal anti bodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR
antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.”

The main route of Al excretion is the urine; therefore, subjects with kidney malfunction or immature kidney, such as nephropathy patients or neonates, might experience toxic accumulation of Al in the body [12]. Infant formula is the primary food source for bottle-fed neonates. The study of Yuan et al reviewed several other studies and reported that most commercial infant formulas contained higher Al (6.5 ฮผM to 87 ฮผM) than human breast milk (0.2 ฮผM to 1.7 ฮผM) [12]. Infants display rapid growth and their brain-blood-barrier, detoxification system (liver), and excretory system (kidney) are not well-developed [13,14]. Aluminum can
cross the blood-brain barrier and accumulate in glial and neural cells [15]. Thus, high intake of Al-containing formula might cause accumulation of Al in the neonatal brain, interfering with appropriate development. In previous studies, exposure to excess dietary Al during gestation and lactation periods had no toxic effects on the mother, but resulted in persistent neurobehavioral deficits in the pups, such as defects in the sensory motor reflexes, locomotor activity, learning capability, and cognitive behavior [16,17]. These behavioral studies, therefore, suggested that Al exposure might cause developmental changes in neonatal brain. Until recently, a marker with which to effectively detect neonatal brain development was lacking. The group’s previous study with Al treatment in neonatal rat hippocampal neurons at concentrations of 37 ฮผM and 74 ฮผM for 14 days significantly reduced NMDAR (N-methyl-D-aspartate receptor) expression which was used as a
marker of brain development. This suggested that Al exposure might influence the development of hippocampal neurons in neonatal rats.

Failure of the excretory system influences elimination of heavy metals and facilitates their accumulation and subsequent manifestation as neurotoxins: the long-term consequences of which would lead to neurodegeneration, cognitive and developmental problems. It may also influence regulation of neural hyperthermia. This article explores the issues and concludes that sensory dysfunction and systemic failure, manifested as autism, is the inevitable consequence arising from subtle DNA alteration and consequently from the overuse of vaccines.

Lasting neuropathological changes in rat brain after intermittent neonatal administration of thimerosal. “These findings document neurotoxic effects of thimerosal, at doses equivalent to those used in infant vaccines or higher, in developing rat brain, suggesting likely involvement of this mercurial in neurodevelopmental  disorders”

The ACIP policy recommendation of routinely administering influenza vaccine during pregnancy is ill-advised and unsupported by current scientific literature, and it should be withdrawn. Use of thimerosal during pregnancy should be contraindicated. adult influenza vaccines contain an equivalent of 25 ยตg of mercury per dose (Table 1). An average-sized pregnant woman receiving an influenza vaccine will be exposed to organic mercury that exceeds the EPA limit by a factor of 3.5
(Table 4). The fetus could potentially receive a dose of mercury that exceeds EPAlimits by a much larger factor. Furthermore, fetal blood mercury concentrations have been shown to be as much as 4.3 times the maternal level. Alarger proportion of ethyl mercury accumulates in fetal tissues relative to maternal tissues, especially in the central nervous system. The observation of a 7.8-15.7% prevalence of elevated umbilical cord mercury in the United States, at levels associated with loss of IQ, adds to the significance of additional mercury exposure from prenatal vaccination.

Autism: a novel form of mercury poisoning “Thimerosal, a preservative added to many vaccines, has become a major source of mercury in children who, within their first two years, may have received a quantity of mercury that exceeds safety guidelines. A review of medical literature and US government data suggests that: (i) many cases of idiopathic autism are induced by early mercury exposure from thimerosal; (ii) this type of autism represents an unrecognized mercurial syndrome; and (iii) genetic and non-genetic factors establish a predisposition whereby thimerosal’s adverse effects occur only in some children.”

'Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.” “Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide. In an initial series of experiments, we examined the potential toxicity of aluminum hydroxide in male, outbred CD-1 mice injected subcutaneously in two equivalent-to-human doses. After sacrifice, spinal cord and motor cortex samples were examined by immunohistochemistry. Aluminum-treated mice showed significantly increased apoptosis of motor neurons and increases in reactive astrocytes and microglial proliferation within the spinal cord and cortex. Morin stain detected the presence of aluminum in the cytoplasm of motor neurons with some neurons also testing positive for the presence of hyper-phosphorylated tau protein, a pathological hallmark of various neurological diseases, including Alzheimer’s disease and frontotemporal dementia. A second series of experiments was conducted on mice injected with six doses of aluminum hydroxide. Behavioural analyses in these mice revealed significant impairments in a number of motor functions as well as diminished spatial memory capacity. The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted.”

A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders. The Institutional Review Board of the Institute for Chronic Illnesses (Office for Human Research Protections, U.S. Department of Health and Human Services, IRB number IRB00005375) approved the present study. A case series of nine patients who presented to the Genetic Centers of America for a genetic/developmental evaluation are discussed. Eight of nine patients (one patient was found to have an ASD due to Rett’s syndrome) (a) had regressive ASDs; (b) had elevated levels of androgens; (c) excreted significant amounts of mercury post chelation challenge; (d) had biochemical evidence of decreased function in their glutathione pathways; (e) had no known significant mercury exposure except from Thimerosal-containing vaccines/Rho(D)-immune globulin preparations; and (f) had alternate causes for their regressive ASDs ruled out. There was a significant dose-response relationship between the severity of the regressive ASDs observed and the total mercury dose children received from Thimerosal-containing vaccines/Rho (D)-immune globulin preparations. Based upon differential diagnoses, 8 of 9 patients examined were exposed to significant mercury from Thimerosal-containing biologic/vaccine preparations during their fetal/infant developmental periods, and subsequently, between 12 and 24 mo of age, these previously normally developing children suffered mercury toxic encephalopathies that manifested with clinical symptoms consistent with regressive ASDs. Evidence for mercury intoxication should be considered in the differential diagnosis as contributing to some regressive ASDs.

Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism: a Report of Three Cases.
In light of encephalopathy presenting as autistic regression (autistic encephalopathy, AE) closely following measles-mumps- rubella (MMR) vaccination, three children underwent cerebrospinal fluid(CSF) assessments including studies for measles virus(MV). All three children had concomitant onset of gastrointestinal (GI) symptoms and had already had MV genomic RNA detected in biopsies ofileal lymphoid nodular hyperplasia(LNH). Presence of MV Fusion(F) gene was examined by TaqMan real- time quantitative polymerase chain reaction (RT-PCR) in cases and control CSF samples. The latter were obtained from three non- autistic MMR-vaccinated children with indwelling shunts for hydrocephalus. None of the cases or controls had a history of measles exposure other than MMR vaccination. Serum and CSF samples were also evaluated for antibodies to MV and myelin basic protein(MBP). MV F gene was present in CSF from all three cases, but not in controls. Genome copy number ranged from 3.7×10 to 2.42×10 per ng of RNA total. Serum anti-MBP autoantibodies were detected in all children with AE. Anti-MBP and MV antibodies were detected in the CSF of two cases, while the third child had neither anti-MBP nor MV antibodies detected in his CSF. Findings are consistent with both an MV (measles virus) etiology for the AE (autistic encephalopathy) and active viral replication in these children. They further indicate the possibility of a virally driven cerebral immunopathology in some cases of regressive autism.

Conclusion:  Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component.

Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined.  Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life.
Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.”

Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate. Our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity.

There is a compelling argument that the occurrence of regressive autism is attributable to genetic and chromosomal abnormalities, arising from the overuse of  vaccines, which subsequently affects the stability and function of the autonomic nervous system and physiological systems.

The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery. Although individuals probably have a genetic predisposition to develop autism, researchers suspect that one or more environmental triggers are also needed. One of those triggers might be the battery of vaccinations that young children receive

Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.

By applying Hill's criteria for establishing causality between exposure and outcome we investigated whether exposure to Al from vaccines could be contributing to the rise in ASD prevalence in the Western world. Our results show that: (i) children from countries with the highest ASD prevalence appear to have the highest exposure to Al from vaccines; (ii) the increase in exposure to Al adjuvants significantly correlates with the increase in ASD prevalence in the United States observed over the last two decades

Eight of nine patients (one patient was found to have an ASD due to Rett's syndrome) (a) had regressive ASDs; (b) had elevated levels of androgens; (c) excreted significant amounts of mercury post chelation challenge; (d) had biochemical evidence of decreased function in their glutathione pathways; (e) had no known significant mercury exposure except from Thimerosal-containing vaccines/Rho(D)-immune globulin preparations; and (f) had alternate causes for their regressive ASDs ruled out

Conjugate vaccines fundamentally change the manner in which the immune systems of infants and young children function by deviating their immune responses to the targeted carbohydrate antigens from a state of hypo-responsiveness to a robust B2 B cell mediated response. This period of hypo-responsiveness to  carbohydrate antigens coincides with the intense myelination process in infants and young children, and conjugate vaccines may have disrupted evolutionary forces that favored early brain development

Recently emerging evidence suggests that mercury, especially from childhood vaccines, appears to be a factor in the development of the autistic disorders

One possible factor underlying these increases is increased exposure to mercury through thimerosal-containing vaccines

This mechanism explains the link between excessive vaccination, use of aluminum and ethylmercury as vaccine adjuvants, food allergies, gut dysbiosis, and abnormal formation of the developing brain. It has now been shown that chronic microglial activation is present in autistic brains from age 5 years to age 44 years

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders.

A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population.

Emerging evidence supports the theory that some autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibility,  specifically a reduced ability to excrete mercury (Hg), and exposure to Hg at critical developmental periods

Documented causes of autism include genetic mutations and/or deletions, viral infections, and encephalitis following vaccination

Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function

We present a singleton case of developmental regression and oxidative phosphorylation disorder in a 19-month-old girl. The patient’s pediatrician diagnosed this as due to varicella vaccination



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package inserts for each vaccine

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/382858

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