Friday, February 22, 2019

vaccines trigger autoimmune disorders, like MS

Multiple sclerosis is an autoimmune disease characterized by demyelination and lymphocyte infiltration of brain tissue. What is known to trigger lymphocyte infiltration of brain tissue?

➡️Pictures 1-5:


Stanley Plotkin is regarded as the Godfather of modern day vaccination, and his writings are the vaccinology bible.

https://www.who.int/.../Elsevier_Vaccine_immunology.pdf...

Pro-Inflammatory cytokines: (IL stands for interleukin)

IL-1
TNF-A
IL-2
IFN-Y
IFN-A
IL-6 
IL-12
IL-15
IL-16
IL-17
IL-18

"Autoimmune diseases result from complex interactions among different immune cell types, including both T and B lymphocytes and professional antigen-presenting cells, such as macrophages and dendritic cells. These cellular interactions result in auto-aggressive responses that target a number of different cell types in different tissues and organs in a relatively large number of autoimmune disorders."

https://www.semanticscholar.org/.../09c23c1fce7b1c1a10b02...

➡️Picture 6:

"This slide is a synthesis of the immunopathogenesis hypothesis of MS. ➡️The belief is that MS is triggered by the peripheral activation of proinflammatory Th1 cells, Th17 cells, and B cells by myelin or microbial antigens presented by professional APCs and B cells.⬅️These cells adhere to and migrate through the BBB and trigger inflammation within the CNS. Recent evidence suggest that migration of CCR6-expressing Th17 cells through the ➡️choroid plexus⬅️ into the subarachnoid space represents the first wave of inflammation, resulting in activated BBB endothelial cells. This is followed by adherence and migration of Th1 and B cells across the BBB into the CNS. Chemokines and microglial cells contribute to inflammation in the CNS. The proinflammatory Th1 and Th17 in the CNS activate monocytes to mediate myelin and axonal injury." 

➡️Picture 7:

T-Cell subsets

➡️Picture 8:

Cytokine Imbalance in MS. What causes cytokine imbalance on purpose? Vaccines.

➡️Picture 9:

The Ventricular System of the Human Brain
The choroid plexus mediates the production of cerebrospinal fluid (CSF). You could say it's very important.

➡️A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice.

https://www.ncbi.nlm.nih.gov/pubmed/26576725

➡️Post-vaccination Accumulation of the Influenza Virus Antigen in the Rat Choroid Plexus 

https://link.springer.com/article/10.1007/s11062-017-9682-2

➡️Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435759/

➡️Picture 10:

Serum cytokines affected in multiple sclerosis (MS) cases as compared to control.

➡️Picture 11 & 12:

Effector Mechanisms Triggered by Vaccines. They're literally telling you their vaccines trigger what is causing your MS. 
Also take note of "Rapid secondary effectors responses in periphery"

How do immune cells overcome the blood–brain barrier in multiple sclerosis?

https://www.sciencedirect.com/.../pii/S001457931100336X

"In this review, we describe how immune cells from the peripheral blood overcome the BBB and promote CNS inflammation in MS through BBB disruption."

Imagine that? 

"Leukocytes can access the CNS compartment (brain, spinal cord and CSF) either via the ➡️choroid plexus and the leptomeningeal vessels, to enter the CSF, or by the parenchymal capillaries and post-capillary venules, to enter the perivascular space." 

➡️Picture 13:

Fig. 1. Effect of cytokines, reactive oxygen species (ROS) and matrix metalloproteinases (MMPs) produced by peripheral blood mononuclear cells (PBMCs) that can directly disrupt components of the BBB or act on receptors expressed by BBB-ECs.

The same cytokines said to cause MS are triggered by vaccines, on purpose.

They found that T lymphocytes were recruited from the periphery to the choroid plexus (CP) of the lateral and third (3rd) ventricles in pregnant mice vaccinated with AIV.

Vaccination causes viral antigen deposits that accumulate in the Choroid Plexus.


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